I am trying to collect all NMR assigned IDPs and put the information in this blog. If you read this news and know something I don’t collect yet, please please write me a comment. It will be very very helpful to me and other guys they want to study IDPs.
Update (3/6/08):
I found that BMRB has a special collection called “Unfolded Protein NMR Entries“. It ’s helpful but the entries are not many.
Just put in a mutation that destabilizes the protein by about 8 kcal/mol and you have an intrinsically disordered protein.
Or take away a metal or reduce a disulfide bond. Or cut an NMR-suitable fragment out of a ribosome. At 10-residues a publication, you’ll have an impressive CV by the time you finish the whole ribosome.
Or go through the garbage dumps of your typical structural genomics factory – the HSQCs that didn’t quite make it into Cell or Science are “intrinsically denatured” and can be recycled for a publication in a lower impact factor journal.
There should be a database … come my way NIH money, It’s a database. On the internet. Lordy lordy it’s a database!
Comment by Andrei — November 18, 2008 @ 12:03 pm |