[web] online predictions of natively unfolded regions in protein

Natively unfolded protein, or so called intrinsically disordered protein, natively disordered protein is a growing topic for protein chemist. Try to collect sever online servers doing sequence-based prediction of the natively unfolded regions in a protein.

• Tango: A computer algorithm for prediction of aggregating regions in unfolded polypeptide chains

  Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol. 2004 Oct;22(10):1302-6. Epub 2004 Sep 12. Fernandez-Escamilla AM, Rousseau F, Schymkowitz J, Serrano L. [link]

• AGGRESCAN: a server for the prediction and evaluation of “hot spots” of aggregation in polypeptides.

  reference: AGGRESCAN: a server for the prediction and evaluation of “hot spots” of aggregation in polypeptides. BMC Bioinformatics. 2007 Feb 27;8:65. Conchillo-Solé O, de Groot NS, Avilés FX, Vendrell J, Daura X, Ventura S. [link]

• The Ucon server [predictionprotein.org]

  reference:

  Natively unstructured regions in proteins identified from contact predictions. Bioinformatics. 2007 Aug 20, Schlessinger A, Punta M, Rost B. [link]

• PreLink Prediction of Linker Regions in Protein Sequence

  reference:

  Prediction of unfolded segments in a protein sequence based on amino acid composition.

  Bioinformatics. 2005 May 1;21(9):1891-900. Epub 2005 Jan 18. Coeytaux K, Poupon A. [link]

More sites will be added soon….